Posted: Tuesday, March 5, 2024
Among patients with ultra–high-risk, newly diagnosed multiple myeloma, those more likely than others to relapse early after intensified treatment included patients with three or more high-risk cytogenetic abnormalities, an SKY92 high-risk signature, or del (17p) combined with an SKY92 high-risk signature, according to research results of an exploratory analysis presented during the 2023 American Society of Hematology (ASH) Annual Meeting & Exposition (Abstract 881). Taking baseline clinical, laboratory, and tumor molecular characteristic factors into account may help with early identification of patients who would be potential candidates for “novel, innovative first-line therapeutic approaches,” noted Martin F. Kaiser, MD, FRCP, FRCPath, of the Royal Marsden Hospital NHS Foundation Trust, London, and colleagues.
Followed for a median of 51.5 months, patients received up to six cycles of daratumumab, bortezomib, lenalidomide, cyclophosphamide, and dexamethasone induction; bortezomib-augmented autologous stem cell transplantation; six cycles of daratumumab, bortezomib, lenalidomide, and dexamethasone (consolidation 1); and 12 cycles of daratumumab, bortezomib, and lenalidomide (consolidation 2). They then moved to monthly daratumumab and lenalidomide maintenance until disease progression. A total of 23 of the 107 patients (21%) experienced early relapse (defined by multiple myeloma relapse or multiple myeloma–related death within 18 months of registration) vs 84 patients (79%) who did not.
Here are some of the team’s findings:
Disclosure: For full disclosures of the study authors, visit ash.confex.com.
2023 ASH Annual Meeting & Exposition