Melanoma Coverage from Every Angle

Is There A Relationship Between Daily Aspirin Therapy and Melanoma Risk?

By: Kayci Reyer
Posted: Wednesday, July 25, 2018

Men taking once-daily aspirin have almost twice the risk to develop melanoma as men who are not on a daily aspirin therapy, according to a study from the Research on Adverse Drug Events And Reports (RADAR) project. However, the study, published in the Journal of the American Academy of Dermatology, was conducted by Beatrice Nardone, MD PhD, of Northwestern University Feinberg School of Medicine, and colleagues, did not recognize an increased risk for melanoma in women on daily aspirin therapy.

“This does not mean men should stop aspirin therapy to lower the risk of heart attack,” Dr. Nardone emphasized in a Northwestern University press release. She suggested that health-care providers be aware of the possible link between melanoma and once-daily aspirin use in men and increase patient education about melanoma prevention.

The study comprised 195,140 men and women aged 18 to 89 with no history of melanoma. Of those participants, the study focus was on the 1,187 patients with at least 1 year of daily aspirin exposure (81 or 325 mg) between January 2005 and December 2006. At 5-year follow-up, 2.19% of aspirin-exposed patients experienced a subsequent melanoma diagnosis, compared with 0.86% of aspirin-unexposed patients. When separated by gender, the adjusted relative risk for aspirin-exposed men was 1.86 compared with aspirin-unexposed men.

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