Thoracic Cancers Symposium 2019: Local Consolidative Therapy for Oligometastatic NSCLC
Posted: Monday, March 18, 2019
Local consolidative therapy seems to improve overall survival in patients with oligometastatic non–small cell lung cancer (NSCLC), according to a study conducted by researchers at The University of Texas MD Anderson Cancer Center, Houston. In results presented at the 2019 Multidisciplinary Thoracic Cancers Symposium in San Diego (Abstract 1), the intensive treatment extended the median overall survival by 6 months for patients diagnosed with 3 or fewer metastases outside of the lungs.
“Local consolidative therapy to all sites of disease with surgery, radiation therapy, or a combination of the two appears to show promise in prolonging overall survival,” explained Erin Corsini, MD, a clinical research fellow at MD Anderson Cancer Center, in an American Society for Radiation Oncology (ASTRO) press release. “The patients who seem to gain the most benefit are those with more favorable disease characteristics, such as adenocarcinoma, early intrathoracic stage, and absence of bone metastases.”
The study included 194 patients with stage IV NSCLC who had been diagnosed with 1 to 3 synchronous metastatic tumors. The majority of patients (70%) had 2 to 3 distant metastases, and nearly all patients (90%) received systemic therapy in addition to local consolidative therapy.
After a median follow-up of 52 months, the median overall survival was 29 months for patients who received local consolidative therapy to all sites compared with 23 months for patients who did not (P = .03). The results also indicated that local consolidative therapy to the primary tumor improved control of local and regional recurrences as well as trended toward an association with improved overall survival (P = .08).
“Our results from evaluating a relatively large group of patients are not only consistent with, but arguably bolster, previously reported findings,” concluded Dr. Corsini.
Disclosure: The study authors’ disclosure information may be found at thoracicsymposium.org.
